×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
CausalMutation
disease
CLINVAR
×
Entrez Id:
29126
Gene Symbol:
CD274
CD274
0.010
AlteredExpression
disease
BEFREE
Interferon-γ-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway.
22204817
2012
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
CTD_human
Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.
25877301
2015
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
GENOMICS_ENGLAND
Perinatal deaths in a family with autosomal dominant polycystic kidney disease and a PKD2 mutation.
18635443
2008
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
GENOMICS_ENGLAND
Neonatal onset autosomal dominant polycystic kidney disease (ADPKD) in a patient homozygous for a PKD2 missense mutation due to uniparental disomy.
22114106
2012
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
CTD_human
N-glycosylation determines the abundance of the transient receptor potential channel TRPP2.
24719335
2014
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
BEFREE
Multiple postnatal craniofacial anomalies are characterized by conditional loss of polycystic kidney disease 2 (Pkd2 ).
23390131
2013
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
GENOMICS_ENGLAND
Mutational screening of PKD2 gene in the north Indian polycystic kidney disease patients revealed 28 genetic variations.
29321346
2017
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
MGD
Cardiac defects and renal failure in mice with targeted mutations in Pkd2.
10615132
2000
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
CTD_human
Altered expression pattern of polycystin-2 in acute and chronic renal tubular diseases.
12089381
2002
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
BEFREE
We generated the first inducible, smooth muscle-specific knockout mice for a TRP channel, namely for PKD2 (TRPP1 ), to investigate arterial myocyte and blood pressure regulation by this protein.
30511640
2018
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
MGD
Somatic inactivation of Pkd2 results in polycystic kidney disease.
9568711
1998
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
MGD
Hepato-renal pathology in pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease.
20093497
2010
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
MGD
Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.
25574838
2015
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
GENOMICS_ENGLAND
Type of PKD1 mutation influences renal outcome in ADPKD.
23431072
2013
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
GENOMICS_ENGLAND
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
CTD_human
The TRPP2-dependent channel of renal primary cilia also requires TRPM3.
30883612
2019
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
CTD_human
Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells.
15001556
2004
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
MGD
Two populations of node monocilia initiate left-right asymmetry in the mouse.
12859898
2003
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
MGD
Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors.
16301212
2006
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
MGD
The ion channel polycystin-2 is required for left-right axis determination in mice.
12062060
2002
×
Entrez Id:
5311
Gene Symbol:
PKD2
PKD2
0.970
Biomarker
disease
CTD_human
Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease.
28887310
2017
×
Entrez Id:
5310
Gene Symbol:
PKD1
PKD1
0.370
Biomarker
disease
CTD_human
Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease.
28887310
2017
×
Entrez Id:
5310
Gene Symbol:
PKD1
PKD1
0.370
Biomarker
disease
CTD_human
Altered expression pattern of polycystin-2 in acute and chronic renal tubular diseases.
12089381
2002
×
Entrez Id:
5310
Gene Symbol:
PKD1
PKD1
0.370
Biomarker
disease
CTD_human
A novel nonsense mutation in the PKD1 gene (C3817T) is associated with autosomal dominant polycystic kidney disease (ADPKD) in a large three-generation Italian family.
7581371
1995